LI-COR, Inc. 4647 Superior Street P.O.Box 4425 Lincoln, NE 68504 USA Phone: (402) 467-0700 Toll Free: (800) 447-3576 Fax: (402) 467-0819 www.licor.com

MATERIAL SAFETY DATA SHEET

1. PRODUCT IDENTIFICATION

IRDye HIV-1 Protease Assay Kit,--926-08588

2. COMPOSITIONS AND INFORMATION ON INGREDIENTS

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   Chemical Name       CAS#            W/V%       EXPOSURE LIMITS IN AIR-OSHA
   NE = NOT ESTABLISHED                           PEL       STEL       IDLH      OTHER
                                                 mg/m3      mg/m3      mg/m3     mg/m3
 
Kit Components IRDye HIV-1 Protease Assay Kit
Component A: IRDye labeled HIV-1 protease peptide substrate, lyophilized
   None of the components in this mixture have an established exposure limit, or contribute
   significantly to the hazards associated with the product.  All hazard information pertinent to this 
   product has been provided in this Material Safety Data Sheet per requirements of the OSHA
   Hazard Communication Standard (29 CFR 1910.1200)
Component B: IRDye800CW fluorescence standard, lyophilized
   None of the components in this mixture have an established exposure limit, or contribute
   significantly to the hazards associated with the product.  All hazard information pertinent to this 
   product has been provided in this Material Safety Data Sheet per requirements of the OSHA
   Hazard Communication Standard (29 CFR 1910.1200)
Component C: Pepstatin A 
   Methyl Sulfoxide    67-68-5        >.99        NE         NE        NE         NE
Component D: HIV Protease Assay Buffer 
   Sodium acetate     127-09-3        <.01        NE         NE        NE         NE
   Sodium chloride   7647-14-5        <.01        NE         NE        NE         NE
   EDTA               600-00-4        <.01        NE         NE        NE         NE
   Bovine serum 
       albumin (BSA) 9048-46-8        <.01        NE         NE        NE         NE
   Water             7732-18-5       Balance      NE         NE        NE         NE
Component E: HIV Protease Stop Solution
   Potassium phosphate 
           monobasic 7778-77-0        <.01        NE         NE        NE         NE
   Potassium Phosphate 
           Dibasic   7758-11-4        <.01        NE         NE        NE         N 
   Water             7732-18-5       Balance      NE         NE        NE         NE


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3. HAZARD IDENTIFICATION

Component C: Methyl Sulfoxide

Hazard Symbols:
     Irritant
Risk Phrases:
     R36/37/38  Irritating to eyes, respiratory system and skin.
Safety Phrases:
      S26, 36/37/39, 45 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.  Wear suitable protective clothing, gloves and eye/face protection.  In case of of accident or if you feel unwell seek medical advice immediately (show label where possible).

Classification system: The classification was made according to the latest editions of the EU lists, and expanded upon from company literature data.

4. FIRST AID MEASURES

Skin Exposure: Caused irritation to skin.  Symptoms include redness, itching and pain.  May cause scaling.  Readily absorbed through the skin.  Garlic-like taste and odor may develop on the breath and skin.  Transient disturbances of color vision, headache, diarrhea and dermatitis may result from skin applications.   A solvent; may result in the increase skin absorption of other more toxic materials.  Remove any contaminated clothing, taking care not to contaminate eyes.
Eye Exposure: Causes irritation, redness and pain.  May cause blurred vision.  If liquids or vapors of this product's components enter the eyes, open victim's eyes while under gently running water.  Use sufficient force to open eyelids.  Have victim "roll" eyes.  Minimum flushing is for 15 minutes.
Inhalation: Causes irritation to the respiratory tract.  Symptoms may include coughing, shortness of breath.  May cause allergic reaction in sensitive individuals.  If vapors, mists or sprays of the products components are inhaled, causing irritation, remove victims to fresh air.  If necessary, use artificial respiration to support vital functions.  Remove or cover gross contamination to avoid exposure to rescuers.
Ingestion: Causes irritation to the gastrointestinal tract.   Symptoms may include nausea, vomiting and diarrhea.  May cause abdominal pain, drowsiness, chills and chest pain. If this product is swallowed, CALL PHYSICIAN OR POISON CONTROL CENTER FOR MOST CURRENT INFORMATION.  If professional advice is not available, do not induce vomiting.  Victim should drink milk, egg whites, or large quantities of water.  Never induce vomiting or give diluents (milk or water) to someone who is unconscious, having convulsion, or unable to swallow.

Victims of chemical exposure must be taken for medical attention.  Rescuers should be taken for medical attention, if necessary.  Take copy of label and MSDS to physician or health professional with victim.

5. FIRE-FIGHTING MEASURES

Unusual Fire And Explosion Hazards: When involved in a fire, this material may decompose and produce irritating fumes and toxic gases.
Flash Point: N/A
Auto ignition Temperature: N/A
Flammable Limits (In Air By Volume, %): LEL:, UEL: N/A
Fire Extinguishing Materials: Use dry chemical, foam or carbon dioxide.

6. ACCIDENTAL RELEASE MEASURES

Spill And Leak Response: Ventilate area of leak or spill.  Remove all sources ignition.  Wear appropriate personal protective equipment as specified in Section 8.  Isolate hazard area.  Keep unnecessary and unprotected personnel from entering.  Contain and recover liquid when possible.  Use non-sparking tools and equipment.  Collect liquid in an appropriate container or absorb with an inert material.  (e.g. vermiculite, dry sand, earth) and place in a chemical container.  Do not flush to sewer!

In the event of a non-incidental, minimum release, Personal Protective Equipment should be:

Level D: lab gloves, chemical resistant apron, boots and splashes goggles.    Absorb spilled liquid with poly pads or other suitable absorbent materials.  Decontaminate the area thoroughly.  Place all spill residues in a suitable container and seal.  Dispose of in accordance with Federal, State and local hazardous waste disposal regulation.

7. HANDLING and STORAGE

Work Practices And Hygiene Practices: As with all chemicals, avoid getting this product ON YOU or IN YOU.  Wash hands after handling this product.  Avoid splashing or spraying this product.  Do not eat or drink while handling this product.
Storage And Handling Practices: All employees who handle this material should be trained to handle it safely.  Avoid breathing vapors or mists generated by this product. Ensure that containers of this product are properly labeled.  Open containers slowly on a stable surface.  Store vials as directed in the product insert.  Keep vials tightly closed when not in use.  Store away from incompatible materials.  Inspect vials containing this product for leaks or damage.  Prior to use, read instruction provided with product.
Protective Practices During Maintenance Of Contaminated Equipment:  Follow practices indicated in Section 6. (Accidental Release Measures).  Make certain that application equipment is locked and tagged-out safely, as applicable.  Always use this product in areas where adequate ventilation is provided.  Decontaminate equipment using soapy water before maintenance begins.  Collect all rinsates and dispose of according to applicable Federal, State or Local procedures.

8. EXPOSURE CONTROLS-PERSONAL PROTECTION

Ventilation And Engineering Controls: Use with adequate ventilation.  Use a mechanical fan or vent area to outside, if necessary.  Eye-wash stations should be available near location where his product is used.
Respiratory Protection: Respiratory protection is generally not needed when using this product.  Maintain airborne contaminant concentration below limits listed in Section 2. (Composition and Information on Ingredients).  If respiratory protection is needed, use only protection authorized in 29 CFR 1910.134 or applicable State regulations. Use supplied air respiration protection if oxygen levels are below 19.5% or are unknown.
Eye Protection: Splash goggles, safety glasses or full face shield where splashing is possible.
Skin Protection: Wear impervious protective clothing, including gloves, lab coat, apron as appropriate to prevent skin contact.

9. PHYSICAL and CHEMICAL PROPERTIES

10. STABILITY and REACTIVITY

Stability: Stable
Decomposition Products: Will not occur.
Hazardous Polymerization: Will not occur.
Conditions To Avoid: Heat, flames, ignition sources and incompatible chemicals.

11. TOXICOLOGICAL INFORMATION

Toxicity Data:The specific toxicology data available for components greater than 1% in concentration are as follows:
Suspected Cancer Agent: The chemicals in the product's solutions are not found on the following lists: NTP, IARC, Federal OSHA Z-list and CAL-OSHA, and therefore are not considered to be, nor suspected by these agencies, to be cancer causing agents.
Irritancy Of Product: Prolonged skin over-exposure to this component may cause dermatitis (red, dry skin).  Eye over-exposure may cause temporary cornea damage.
Sensitization To The Product: The chemicals in this product's solutions are not know to be sensitizer with prolonged or repeated use.
Reproductive Toxicity Information: Listed below is information concerning the effects of this product and its components on the human reproductive system.
Mutagenicity: This product is not reported to produce mutagenic effects in humans. 
Embryo toxicity: This product is not reported to cause human teratogenic effects.  Refer to the following paragraph for additional information.
Teratogenicity: This product is not reported to cause human teratogenic effects.
Reproductive Toxicity: This product is not reported at this time to cause adverse reproductive effects in humans. 
Medical Condition Aggravated By Exposure:  Skin disorders may be aggravated by over-exposure to Dimethyl Sulfoxide.  No specific medical conditions are known to be aggravated by exposure to other solutions of this product.
Biological Exposure Indices (BEI's): Currently, there are no Biological Exposure Indices (BEI's) applicable to the components of this product.

12. ECOLOGICAL INFORMATION

Environmental Stability: When released into the soil, this material is not expected to biodegrade.  When released into the soil, this material may leach into the groundwater this material may evaporate to a moderate extent.  When released into water, this material may evaporate to a moderate extent.  This material is not expected significantly to bio accumulate.  When released in to the air, this material may be moderately degraded by reaction with photochemical produced hydroxyl radicals.  When released into the air, this material may be removed from the atmosphere to a moderate extent by wet deposition.
Effect Of Material On Plants Or Animals: No information found.

13. DISPOSAL CONSIDERATIONS

Preparing Wastes For Disposal: Waste Disposal must be in accordance with appropriate Federal, State and local regulation.  This product, if altered by use, may be disposed of by treatment at a permitted facility or as advised by your local hazardous waste regulatory authority.
EPA Waste Number: Not applicable to this product.

14. TRANSPORTATION INFORMATION

This material is not hazardous as defined by 49 CFR 172.101 by the U.S. Department of Transportation.  This material is not considered as Dangerous Goods.

Proper Shipping Name: N/A
Hazard Class Number And Description: N/A
UN Identification Number: N/A
Packing Group: N/A

15. REGULATORY INFORMATION

SARA Reporting Requirements: These chemicals are not subject to Sections 302, 304, and 313 reporting requirements under the Superfund Amendment and Reauthorization Act.

Chemical                                               SARA 302                          SARA 304                        SARA 313

SARA Threshold Planning Quantity: N/A
TSCA Inventory Status: The components of this product are listed on the TSCA inventory.

CERCLA Reportable Quantity (RQ): N/A
Other Federal Regulations: N/A

16. OTHER INFORMATION